{"id":238,"date":"2010-06-20T03:29:57","date_gmt":"2010-06-20T03:29:57","guid":{"rendered":"http:\/\/www.leonbergerclubofcanada.com\/blog\/"},"modified":"2018-02-16T11:26:08","modified_gmt":"2018-02-16T15:26:08","slug":"new-genetic-test-for-leonberger-polyneuropathy","status":"publish","type":"page","link":"https:\/\/www.leonbergerclubofcanada.com\/blog\/the-leonberger\/health\/new-genetic-test-for-leonberger-polyneuropathy\/","title":{"rendered":"Interpretation of Genetic Tests for Leonberger Polyneuropathy and LEMP"},"content":{"rendered":"<p><strong>LPN1 Genetic Test Result Interpretation<\/strong><br \/>\nClear (LPN1-N\/N): A clear dog has no copies of the LPN1 gene mutation (this is also referred to as being<br \/>\nhomozygous normal). However, this result does not rule out the possibility that a dog could have, or be a carrier<br \/>\nfor, a different polyneuropathy mutation (including LPN2) that this test cannot detect. A LPN1 clear dog cannot<br \/>\nproduce a LPN1-D\/D dog.<br \/>\nCarrier\/At Risk (LPN1-D\/N): A carrier\/at risk dog has one copy of the LPN1 gene mutation (this is also<br \/>\nreferred to as being heterozygous). Having one copy of the mutated form of the LPN1 gene does not rule out the<br \/>\npossibility that a dog may have a polyneuropathy caused by the LPN1 mutation or another mutation not<br \/>\ndetected by this test (including LPN2). LPN1 carriers will, on average, pass the LPN1 gene mutation on to half<br \/>\nof their offspring.<br \/>\nAffected (LPN1-D\/D): An affected dog has two copies of the LPN1 gene mutation (this is also referred to as<br \/>\nbeing homozygous affected). Affected dogs typically develop neurological disease at or before 3 years of age<br \/>\n(average 1.9 years of age), and clinical signs tend to be severe, often requiring surgical intervention of laryngeal<br \/>\nparalysis. Affected dogs will pass one copy of this mutation on to all of their offspring.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>LPN2 Genetic Test Result Interpretation<\/strong><br \/>\nClear (LPN2-N\/N): A clear dog has no copies of the LPN2 gene mutation (this is also referred to as being<br \/>\nhomozygous normal). However, this result does not rule out the possibility that a dog could have, or be a carrier<br \/>\nfor, a different polyneuropathy mutation (including LPN1) that this test cannot detect.<br \/>\nHeterozygous Affected\/Susceptible (LPN2\u2013D\/N): A heterozygous affected\/susceptible dog has one copy of<br \/>\nLPN2 gene mutation. The average age that owners first notice clinical signs of PN in heterozygous affected<br \/>\ndogs, if they develop at all, is 6 years. On average, heterozygous affected dogs will pass along the LPN2<br \/>\nmutation to half of their offspring, this half will be LPN2 affected\/susceptible.<br \/>\nHomozygous Affected\/Susceptible (LPN2\u2013D\/D): A homozygous affected\/susceptible dog has two copies of<br \/>\nthe LPN2 gene mutation. In a limited number of homozygous affected dogs, the average age of onset is 4.5<br \/>\nyears. Affected dogs will pass one copy of this mutation on to all of their offspring, and all will be LPN2<br \/>\naffected\/susceptible.<\/p>\n<p><strong>LEMP Genetic Test Result Interpretation<\/strong><br \/>\nClear (LEMP-N\/N): A clear dog has no copies of the LEMP mutation (this is also referred to as being<br \/>\nhomozygous normal or free of the known mutation causing leukoencephalomyelopathy). A clear dog cannot<br \/>\nproduce LEMP affected (D\/D) offspring.<br \/>\nCarrier (LEMP-D\/N): A carrier dog has one copy of the LEMP gene mutation (this is also referred to as<br \/>\nbeing heterozygous). A carrier dog is a healthy dog, and is not at risk of developing LEMP. LEMP carriers<br \/>\nwill, on average, pass the LEMP gene mutation on to half of their offspring; they can produce LEMP-D\/D<br \/>\n(affected\/susceptible) offspring if mated to another carrier or affected dog.<br \/>\nAffected\/Susceptible (LEMP-D\/D): An affected\/susceptible dog has two copies of the LEMP gene mutation<br \/>\n(this is also referred to as being homozygous affected). LEMP-D\/D dogs often develop<br \/>\nleukoencephalomyelopathy at or before 3 years of age and clinical signs are characterized by slowly worsening<br \/>\ngait abnormalities, especially spontaneous knuckling, dragging of the paws and hypermetria of the thoracic<br \/>\nlimbs, and a characteristic pattern on magnetic resonance imaging (MRI). Affected dogs show corresponding<br \/>\ngross lesions in the cervical spinal cord white matter that may extend to the thoracic spinal cord, as well as to<br \/>\nthe brain; peripheral nerve and muscle biopsies are unremarkable. Spinal reflexes of affected dogs are mostly<br \/>\nnormal. In the progressive clinical course of the disease, affected dogs may become increasingly immobile<br \/>\nwithin a few months. Like many diseases of the CNS, there is no effective treatment for LEMP. Since in most<br \/>\ncases the dog is not in pain, but is strongly restricted in its quality of life, owners are encouraged to ask a<br \/>\nveterinarian for advice. LEMP-D\/D dogs will pass one copy of this mutation on to all of their offspring.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>LPN1 Genetic Test Result Interpretation Clear (LPN1-N\/N): A clear dog has no copies of the LPN1 gene mutation (this is also referred to as being homozygous normal). However, this result does not rule out the possibility that a dog could have, or be a carrier for, a different polyneuropathy mutation (including LPN2) that this test [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":127,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-238","page","type-page","status-publish","hentry","entry"],"_links":{"self":[{"href":"https:\/\/www.leonbergerclubofcanada.com\/blog\/wp-json\/wp\/v2\/pages\/238","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.leonbergerclubofcanada.com\/blog\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.leonbergerclubofcanada.com\/blog\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.leonbergerclubofcanada.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.leonbergerclubofcanada.com\/blog\/wp-json\/wp\/v2\/comments?post=238"}],"version-history":[{"count":5,"href":"https:\/\/www.leonbergerclubofcanada.com\/blog\/wp-json\/wp\/v2\/pages\/238\/revisions"}],"predecessor-version":[{"id":2440,"href":"https:\/\/www.leonbergerclubofcanada.com\/blog\/wp-json\/wp\/v2\/pages\/238\/revisions\/2440"}],"up":[{"embeddable":true,"href":"https:\/\/www.leonbergerclubofcanada.com\/blog\/wp-json\/wp\/v2\/pages\/127"}],"wp:attachment":[{"href":"https:\/\/www.leonbergerclubofcanada.com\/blog\/wp-json\/wp\/v2\/media?parent=238"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}